NTSR1
Gene Information
- Official Symbol: NTSR1
- Official Name: neurotensin receptor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 4923
- UniProt: P30989
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197). {ECO:0000269|PubMed:21725197, ECO:0000269|PubMed:23140271, ECO:0000269|PubMed:8381365}.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
| 7TM GPCR Srv |
GO Terms
| G protein-coupled neurotensin receptor activity |
| positive regulation of gamma-aminobutyric acid secretion |
| D-aspartate import across plasma membrane |
| D-aspartate transport |
| symmetric synapse |
| regulation of gamma-aminobutyric acid secretion |
| positive regulation of arachidonic acid secretion |
| modulation of inhibitory postsynaptic potential |
| positive regulation of inhibitory postsynaptic potential |
| D-amino acid transport |
| L-glutamate import across plasma membrane |
| regulation of arachidonic acid secretion |
| L-glutamate import |
| positive regulation of glutamate secretion |
| positive regulation of inositol phosphate biosynthetic process |
| negative regulation of release of sequestered calcium ion into cytosol |
| detection of temperature stimulus involved in sensory perception |
| detection of temperature stimulus involved in sensory perception of pain |
| amino acid import across plasma membrane |
| regulation of inositol phosphate biosynthetic process |
| regulation of glutamate secretion |
| inositol phosphate catabolic process |
| positive regulation of sequestering of calcium ion |
| positive regulation of icosanoid secretion |
| positive regulation of amino acid transport |
| negative regulation of systemic arterial blood pressure |
| negative regulation of calcium ion transport into cytosol |
| positive regulation of fatty acid transport |
| L-glutamate transmembrane transport |
| regulation of icosanoid secretion |
| detection of temperature stimulus |
| sensory perception of temperature stimulus |
| amino acid import |
| regulation of respiratory gaseous exchange |
| C4-dicarboxylate transport |
| positive regulation of alcohol biosynthetic process |
| polyol catabolic process |
| regulation of fatty acid transport |
| neurotransmitter uptake |
| temperature homeostasis |
| regulation of amino acid transport |
| positive regulation of organic acid transport |
| positive regulation of amine transport |
| dendritic shaft |
| positive regulation of neurotransmitter transport |
| regulation of sensory perception of pain |
| negative regulation of calcium ion transmembrane transport |
| positive regulation of release of sequestered calcium ion into cytosol |
| regulation of sensory perception |
| regulation of membrane depolarization |
| negative regulation of blood pressure |
| L-alpha-amino acid transmembrane transport |
| acidic amino acid transport |
| terminal bouton |
| regulation of action potential |
| positive regulation of anion transport |
| cytoplasmic side of plasma membrane |
| positive regulation of calcium ion transport into cytosol |
| alcohol catabolic process |
| inositol phosphate metabolic process |
| regulation of organic acid transport |
| positive regulation of cellular carbohydrate metabolic process |
| L-amino acid transport |
| negative regulation of calcium ion transport |
| positive regulation of lipid transport |
| positive regulation of nervous system process |
| positive regulation of cation channel activity |
| positive regulation of calcium ion transmembrane transport |
| drug transmembrane transport |
| regulation of alcohol biosynthetic process |
| sensory perception of pain |
| organic hydroxy compound catabolic process |
| adult locomotory behavior |
| amino acid transmembrane transport |
| regulation of release of sequestered calcium ion into cytosol |
| positive regulation of carbohydrate metabolic process |
| dicarboxylic acid transport |
| positive regulation of lipid localization |
| negative regulation of cation transmembrane transport |
| regulation of amine transport |
| regulation of systemic arterial blood pressure |
| regulation of carbohydrate biosynthetic process |
| negative regulation of ion transmembrane transport |
| regulation of anion transport |
| import across plasma membrane |
| regulation of calcium ion transport into cytosol |
| positive regulation of ion transmembrane transporter activity |
| neuropeptide signaling pathway |
| protein N-terminus binding |
| regulation of lipid transport |
| polyol metabolic process |
| positive regulation of transporter activity |
| negative regulation of transmembrane transport |
| amino acid transport |
| detection of external stimulus |
| positive regulation of calcium ion transport |
| detection of abiotic stimulus |
| regulation of sequestering of calcium ion |
| organic acid transmembrane transport |
| organophosphate catabolic process |
| carboxylic acid transmembrane transport |
| perikaryon |
| regulation of nervous system process |
| regulation of lipid localization |
| positive regulation of small molecule metabolic process |
| regulation of cellular carbohydrate metabolic process |
| positive regulation of cation transmembrane transport |
| regulation of neurotransmitter transport |
| adult behavior |
| learning |
| regulation of calcium ion transmembrane transport |
| negative regulation of ion transport |
| dendritic spine |
| drug transport |
| positive regulation of synaptic transmission |
| positive regulation of ion transmembrane transport |
| regulation of cation channel activity |
| response to temperature stimulus |
| neurotransmitter transport |
| regulation of blood pressure |
| locomotory behavior |
| positive regulation of transmembrane transport |
| regulation of carbohydrate metabolic process |
| membrane raft |
| regulation of calcium ion transport |
| regulation of ion transmembrane transporter activity |
| learning or memory |
| regulation of transmembrane transporter activity |
| positive regulation of ion transport |
| anion transmembrane transport |
| regulation of transporter activity |
| positive regulation of cytosolic calcium ion concentration |
| carboxylic acid transport |
| organic acid transport |
| cognition |
| alcohol metabolic process |
| multicellular organismal homeostasis |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| regulation of neurotransmitter levels |
| regulation of metal ion transport |
| blood circulation |
| circulatory system process |
| positive regulation of secretion by cell |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| regulation of small molecule metabolic process |
| regulation of membrane potential |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| trans-synaptic signaling |
| small molecule catabolic process |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| organic hydroxy compound metabolic process |
| organic anion transport |
| synaptic signaling |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| protein heterodimerization activity |
| divalent inorganic cation homeostasis |
| detection of stimulus involved in sensory perception |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| behavior |
| anion transport |
| regulation of system process |
| cell surface |
| metal ion homeostasis |
| cellular cation homeostasis |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| positive regulation of programmed cell death |
| import into cell |
| detection of stimulus |
| positive regulation of cell death |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| G protein-coupled receptor activity |
| cellular chemical homeostasis |
| regulation of secretion by cell |
| ion homeostasis |
| regulation of secretion |
| response to lipid |
| protein homodimerization activity |
| organophosphate metabolic process |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| regulation of cellular localization |
| ion transmembrane transport |
| sensory perception |
| Golgi apparatus |
| positive regulation of transport |
| negative regulation of cell death |
| endoplasmic reticulum |
| response to drug |
| identical protein binding |
| chemical homeostasis |
| cell-cell signaling |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| response to abiotic stimulus |
| mitochondrion |
| transmembrane transport |
| G protein-coupled receptor signaling pathway |
| ion transport |
| nervous system process |
| integral component of plasma membrane |
| regulation of apoptotic process |
| regulation of programmed cell death |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| nitrogen compound transport |
| regulation of transport |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| PT-1 25μM R07 exp392 | -1.71 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8779
- Expression level (log2 read counts): -5.28
Expression Distribution
NTSR1 Expression in NALM6 Cells: -5.28
