NUCB2

Entrez Summary: N/A
UniProt Summary: Calcium-binding protein. May have a role in calcium homeostasis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11μM R07 exp409	-2.15
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.13
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.06
Cyclosporin-A 3μM R07 exp348	-1.8
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	1.86
UNC2400 2μM R03 exp156	1.88

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of appetite
negative regulation of response to food
negative regulation of response to extracellular stimulus
negative regulation of response to nutrient levels
regulation of response to food
regulation of appetite
regulation of response to nutrient levels
regulation of response to extracellular stimulus
nuclear outer membrane
endoplasmic reticulum-Golgi intermediate compartment
negative regulation of response to external stimulus
response to nutrient levels
response to extracellular stimulus
calcium ion binding
Golgi apparatus
endoplasmic reticulum
regulation of response to external stimulus
DNA binding
extracellular space
negative regulation of response to stimulus