NUDT16L1

Entrez Summary: N/A
UniProt Summary: Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299). {ECO:0000269|PubMed:18820299, ECO:0000269|PubMed:28241136}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Vinblastine 0.002μM R01 exp60	-2.03
Caffeine 2600μM R08 exp463	-1.71

phosphodiesterase decapping endonuclease activity
snoRNA catabolic process
nucleotide phosphatase activity, acting on free nucleotides
negative regulation of double-strand break repair via nonhomologous end joining
m7G(5)pppN diphosphatase activity
snoRNA binding
snoRNA metabolic process
regulation of double-strand break repair via nonhomologous end joining
ncRNA catabolic process
negative regulation of double-strand break repair
negative regulation of DNA repair
regulation of double-strand break repair
negative regulation of response to DNA damage stimulus
negative regulation of DNA metabolic process
regulation of DNA repair
mRNA catabolic process
regulation of response to DNA damage stimulus
RNA catabolic process
regulation of DNA metabolic process
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
ncRNA metabolic process
organic cyclic compound catabolic process
mRNA metabolic process
regulation of cellular response to stress
protein homodimerization activity
cellular macromolecule catabolic process
macromolecule catabolic process
RNA binding
negative regulation of nucleobase-containing compound metabolic process
regulation of response to stress
negative regulation of response to stimulus
RNA metabolic process
negative regulation of gene expression
organic substance catabolic process
cellular catabolic process