NUFIP1

Entrez Summary: This gene encodes a nuclear RNA binding protein that contains a C2H2 zinc finger motif and a nuclear localization signal. This protein is associated with the nuclear matrix in perichromatin fibrils and, in neurons, localizes to the cytoplasm in association with endoplasmic reticulum ribosomes. This protein interacts with the fragile X mental retardation protein (FMRP), the tumor suppressor protein BRCA1, upregulates RNA polymerase II transcription, and is involved in box C/D snoRNP biogenesis. A pseudogene of this gene resides on chromosome 6q12. [provided by RefSeq, Feb 2012].
UniProt Summary: Binds RNA. {ECO:0000269|PubMed:10556305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	1/5

Expression Distribution

perichromatin fibrils
pre-snoRNP complex
cytosolic ribosome
box C/D snoRNP assembly
small nucleolar ribonucleoprotein complex assembly
snoRNA binding
transcription elongation factor complex
presynaptic active zone
protein binding, bridging
ATPase binding
nuclear matrix
fibrillar center
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
ribonucleoprotein complex biogenesis
protein complex oligomerization
protein-containing complex
cellular protein-containing complex assembly
nucleolus
RNA processing
identical protein binding
positive regulation of transcription by RNA polymerase II
RNA binding
DNA binding
positive regulation of transcription, DNA-templated
protein-containing complex assembly
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
positive regulation of RNA metabolic process
protein-containing complex subunit organization
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
gene expression
positive regulation of biosynthetic process