OAS1

Entrez Summary: This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, Feb 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

2-5-oligoadenylate synthetase activity
regulation of ribonuclease activity
regulation of nuclease activity
negative regulation of viral genome replication
cellular response to type I interferon
type I interferon signaling pathway
response to type I interferon
double-stranded RNA binding
interferon-gamma-mediated signaling pathway
negative regulation of viral life cycle
regulation of viral genome replication
negative regulation of viral process
glucose metabolic process
regulation of viral life cycle
hexose metabolic process
cellular response to interferon-gamma
response to interferon-gamma
glucose homeostasis
carbohydrate homeostasis
defense response to virus
monosaccharide metabolic process
regulation of viral process
negative regulation of multi-organism process
regulation of symbiosis, encompassing mutualism through parasitism
response to virus
carbohydrate metabolic process
cytokine-mediated signaling pathway
innate immune response
regulation of multi-organism process
defense response to other organism
cellular response to cytokine stimulus
endoplasmic reticulum
immune effector process
response to cytokine
chemical homeostasis
mitochondrion
regulation of hydrolase activity
response to other organism
response to external biotic stimulus
response to biotic stimulus