OPN4

Entrez Summary: N/A
UniProt Summary: Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all- trans retinal back to 11-cis retinal (By similarity). {ECO:0000250, ECO:0000269|PubMed:10632589, ECO:0000269|PubMed:15674244}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Salubrinal 20μM R07 exp399	1.87
FK-506 30μM R07 exp359	1.95

7tm 1
7TM GPCR Srsx

11-cis retinal binding
G protein-coupled photoreceptor activity
protein-chromophore linkage
photoreceptor disc membrane
phototransduction
detection of visible light
detection of light stimulus
cellular response to light stimulus
regulation of circadian rhythm
detection of external stimulus
detection of abiotic stimulus
cellular response to radiation
visual perception
sensory perception of light stimulus
rhythmic process
response to light stimulus
cellular response to environmental stimulus
cellular response to abiotic stimulus
response to radiation
detection of stimulus
sensory perception
response to abiotic stimulus
G protein-coupled receptor signaling pathway
nervous system process
integral component of plasma membrane
system process