OPRL1

Gene Information

Official Symbol: OPRL1
Official Name: opioid related nociceptin receptor 1
Aliases and Previous Symbols: N/A
Entrez ID: 4987
UniProt: P41146
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. {ECO:0000269|PubMed:11238602, ECO:0000269|PubMed:12568343, ECO:0000269|PubMed:22596163, ECO:0000269|PubMed:23086955, ECO:0000269|PubMed:8137918}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 1μM R00 exp29	-2.04
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-1.94
Artemisinin 50μM R08 exp450	-1.9
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	-1.79

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10047
Expression level (log2 read counts): -0.44

Expression Distribution

7TM GPCR Srv
7tm 1
7TM GPCR Srsx

nociceptin receptor activity
positive regulation of gastric acid secretion
conditioned place preference
regulation of locomotor rhythm
positive regulation of sensory perception of pain
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
opioid receptor signaling pathway
positive regulation of digestive system process
regulation of gastric acid secretion
regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
negative regulation of voltage-gated calcium channel activity
positive regulation of urine volume
estrous cycle
regulation of urine volume
neuropeptide binding
negative regulation of cAMP-mediated signaling
eating behavior
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
negative regulation of calcium ion transmembrane transporter activity
regulation of voltage-gated calcium channel activity
regulation of sensory perception of pain
negative regulation of calcium ion transmembrane transport
regulation of sensory perception
regulation of digestive system process
negative regulation of cation channel activity
negative regulation of blood pressure
negative regulation of G protein-coupled receptor signaling pathway
regulation of cAMP-mediated signaling
peptide binding
negative regulation of calcium ion transport
positive regulation of nervous system process
ovulation cycle
negative regulation of ion transmembrane transporter activity
regulation of behavior
sensory perception of pain
associative learning
negative regulation of transporter activity
negative regulation of cation transmembrane transport
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
feeding behavior