OXA1L

Gene Information

Official Symbol: OXA1L
Official Name: OXA1L mitochondrial inner membrane protein
Aliases and Previous Symbols: N/A
Entrez ID: 5018
UniProt: Q15070
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes an evolutionarily conserved protein that is localized to the inner mitochondrial membrane. The encoded protein is essential for the translocation of the N-terminal tail of subunit 2 of cytochrome c oxidase, and is involved in the assembly of the cytochrome c oxidase and ATPase complexes of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2016].
UniProt Summary: Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria. {ECO:0000269|PubMed:17936786, ECO:0000269|PubMed:7991568}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1610
Expression level (log2 read counts): 7.11

Expression Distribution

Screen	Score
Thimerosal 0.85μM R08 exp529	1.76
PF-06409577 20μM R07 exp389	1.81
A-769662 20μM R07 exp331	1.82

membrane insertase activity
protein insertion into membrane from inner side
protein insertion into mitochondrial inner membrane from matrix
mitochondrial ribosome binding
mitochondrial proton-transporting ATP synthase complex assembly
proton-transporting ATP synthase complex assembly
integral component of mitochondrial membrane
protein insertion into mitochondrial inner membrane
proton-transporting two-sector ATPase complex assembly
mitochondrial respirasome
establishment of protein localization to mitochondrial membrane
negative regulation of ATPase activity
mitochondrial respiratory chain complex IV assembly
protein insertion into mitochondrial membrane
negative regulation of oxidoreductase activity
respiratory chain complex IV assembly
cytochrome complex assembly
integral component of mitochondrial inner membrane
protein insertion into membrane
inner mitochondrial membrane organization
protein targeting to mitochondrion
NADH dehydrogenase complex assembly
mitochondrial respiratory chain complex I assembly
establishment of protein localization to mitochondrion
protein localization to mitochondrion
aerobic respiration
regulation of ATPase activity
mitochondrial translational elongation
mitochondrial translational termination
regulation of oxidoreductase activity
mitochondrial respiratory chain complex assembly
translational termination
mitochondrial membrane
mitochondrial translation
translational elongation
mitochondrial membrane organization
cellular protein complex disassembly
mitochondrial gene expression
protein tetramerization
cellular respiration