P2RY1
Gene Information
- Official Symbol: P2RY1
- Official Name: purinergic receptor P2Y1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5028
- UniProt: P47900
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008].
- UniProt Summary: Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. {ECO:0000269|PubMed:9442040}.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
GO Terms
| A1 adenosine receptor binding |
| ADP-activated adenosine receptor activity |
| ATP-activated adenosine receptor activity |
| positive regulation of penile erection |
| positive regulation of inositol trisphosphate biosynthetic process |
| regulation of penile erection |
| regulation of inositol trisphosphate biosynthetic process |
| negative regulation of norepinephrine secretion |
| adenosine receptor signaling pathway |
| G protein-coupled purinergic nucleotide receptor activity |
| cellular response to purine-containing compound |
| G protein-coupled purinergic nucleotide receptor signaling pathway |
| positive regulation of inositol phosphate biosynthetic process |
| integral component of presynaptic active zone membrane |
| negative regulation of catecholamine secretion |
| regulation of norepinephrine secretion |
| regulation of inositol phosphate biosynthetic process |
| regulation of presynaptic cytosolic calcium ion concentration |
| cellular response to ATP |
| signal transduction involved in regulation of gene expression |
| G protein-coupled purinergic receptor signaling pathway |
| purinergic nucleotide receptor signaling pathway |
| relaxation of muscle |
| negative regulation of amine transport |
| positive regulation of alcohol biosynthetic process |
| purinergic receptor signaling pathway |
| eating behavior |
| response to ATP |
| neuron cellular homeostasis |
| glial cell migration |
| ADP binding |
| positive regulation of cellular carbohydrate metabolic process |
| scaffold protein binding |
| regulation of catecholamine secretion |
| cellular response to nutrient |
| cell body |
| sensory perception of pain |
| regulation of alcohol biosynthetic process |
| regulation of synaptic vesicle exocytosis |
| positive regulation of reproductive process |
| positive regulation of carbohydrate metabolic process |
| adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| feeding behavior |
| regulation of amine transport |
| regulation of carbohydrate biosynthetic process |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| regulation of neurotransmitter secretion |
| regulation of synaptic vesicle cycle |
| positive regulation of hormone secretion |
| response to organophosphorus |
| positive regulation of small molecule metabolic process |
| platelet activation |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| regulation of cellular carbohydrate metabolic process |
| regulation of tube size |
| regulation of neurotransmitter transport |
| regulation of cell shape |
| response to purine-containing compound |
| regulation of reproductive process |
| regulation of regulated secretory pathway |
| vascular process in circulatory system |
| negative regulation of binding |
| regulation of signaling receptor activity |
| protein localization to plasma membrane |
| basolateral plasma membrane |
| cilium |
| postsynaptic membrane |
| negative regulation of secretion by cell |
| regulation of carbohydrate metabolic process |
| signaling receptor activity |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| positive regulation of ERK1 and ERK2 cascade |
| response to mechanical stimulus |
| gliogenesis |
| response to nutrient |
| regulation of exocytosis |
| protein localization to cell periphery |
| negative regulation of secretion |
| cellular response to nutrient levels |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| postsynaptic density |
| cellular response to extracellular stimulus |
| regulation of hormone secretion |
| positive regulation of ion transport |
| aging |
| positive regulation of cytosolic calcium ion concentration |
| blood coagulation |
| regulation of ERK1 and ERK2 cascade |
| coagulation |
| hemostasis |
| muscle system process |
| apical plasma membrane |
| regulation of cytosolic calcium ion concentration |
| cellular response to external stimulus |
| anatomical structure homeostasis |
| glutamatergic synapse |
| regulation of neurotransmitter levels |
| regulation of binding |
| blood circulation |
| circulatory system process |
| cellular response to drug |
| positive regulation of secretion by cell |
| dendrite |
| regulation of small molecule metabolic process |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| wound healing |
| protein localization to membrane |
| negative regulation of transport |
| protein heterodimerization activity |
| regulation of cell morphogenesis |
| divalent inorganic cation homeostasis |
| regulation of body fluid levels |
| response to nutrient levels |
| positive regulation of multi-organism process |
| regulation of anatomical structure size |
| response to growth factor |
| response to extracellular stimulus |
| regulation of hormone levels |
| cellular response to organic cyclic compound |
| positive regulation of MAPK cascade |
| regulation of vesicle-mediated transport |
| cellular metal ion homeostasis |
| response to wounding |
| behavior |
| cellular response to organonitrogen compound |
| cell surface |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cellular response to nitrogen compound |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of multi-organism process |
| ion homeostasis |
| regulation of secretion |
| cellular homeostasis |
| regulation of cellular localization |
| response to organic cyclic compound |
| cell migration |
| sensory perception |
| positive regulation of transport |
| response to organonitrogen compound |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell activation |
| cell motility |
| localization of cell |
| response to nitrogen compound |
| chemical homeostasis |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| response to abiotic stimulus |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| mitochondrion |
| locomotion |
| G protein-coupled receptor signaling pathway |
| nervous system process |
| integral component of plasma membrane |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| ATP binding |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Dynasore 10μM R04 exp180 | -1.91 |
| Betulinic acid 10 to 15μM on day4 R05 exp222 | -1.76 |
| Rapamycin 10μM R00 exp30 | 1.72 |
| Wiskostatin 3μM R07 exp422 | 1.89 |
| MK2206 4μM R08 exp504 | 1.97 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15848
- Expression level (log2 read counts): -3.9
Expression Distribution
P2RY1 Expression in NALM6 Cells: -3.9
