PAK3
Gene Information
- Official Symbol: PAK3
- Official Name: p21 (RAC1) activated kinase 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 5063
- UniProt: O75914
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| PBD |
| Pkinase Tyr |
| Pkinase |
GO Terms
| positive regulation of fibroblast migration |
| MAP kinase kinase activity |
| dendritic spine morphogenesis |
| positive regulation of dendritic spine morphogenesis |
| dendritic spine development |
| regulation of fibroblast migration |
| dendritic spine organization |
| positive regulation of dendrite morphogenesis |
| neuron projection organization |
| regulation of dendritic spine morphogenesis |
| positive regulation of dendritic spine development |
| Rac GTPase binding |
| T cell costimulation |
| positive regulation of neuron apoptotic process |
| lymphocyte costimulation |
| dendrite morphogenesis |
| positive regulation of DNA biosynthetic process |
| regulation of dendritic spine development |
| positive regulation of dendrite development |
| ephrin receptor signaling pathway |
| postsynapse organization |
| regulation of dendrite morphogenesis |
| positive regulation of neuron death |
| regulation of postsynapse organization |
| dendrite development |
| regulation of DNA biosynthetic process |
| stimulatory C-type lectin receptor signaling pathway |
| innate immune response activating cell surface receptor signaling pathway |
| SH3 domain binding |
| stress-activated protein kinase signaling cascade |
| regulation of dendrite development |
| activation of MAPK activity |
| positive regulation of cell morphogenesis involved in differentiation |
| regulation of actin filament polymerization |
| T cell receptor signaling pathway |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| regulation of axonogenesis |
| positive regulation of DNA metabolic process |
| positive regulation of T cell activation |
| regulation of neuron apoptotic process |
| positive regulation of leukocyte cell-cell adhesion |
| regulation of synapse organization |
| regulation of protein polymerization |
| regulation of synapse structure or activity |
| innate immune response-activating signal transduction |
| postsynaptic density |
| positive regulation of cell-cell adhesion |
| activation of innate immune response |
| regulation of actin filament organization |
| positive regulation of MAP kinase activity |
| synapse organization |
| endosome |
| positive regulation of neuron projection development |
| antigen receptor-mediated signaling pathway |
| regulation of leukocyte cell-cell adhesion |
| regulation of cell morphogenesis involved in differentiation |
| regulation of neuron death |
| regulation of T cell activation |
| activation of protein kinase activity |
| positive regulation of protein serine/threonine kinase activity |
| positive regulation of innate immune response |
| regulation of MAP kinase activity |
| regulation of actin cytoskeleton organization |
| glutamatergic synapse |
| regulation of supramolecular fiber organization |
| regulation of DNA metabolic process |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| protein serine/threonine kinase activity |
| positive regulation of neuron differentiation |
| MAPK cascade |
| axonogenesis |
| regulation of cellular component size |
| positive regulation of cell projection organization |
| regulation of actin filament-based process |
| signal transduction by protein phosphorylation |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| axon development |
| positive regulation of cell activation |
| cell morphogenesis involved in neuron differentiation |
| immune response-activating cell surface receptor signaling pathway |
| regulation of protein complex assembly |
| regulation of innate immune response |
| positive regulation of neurogenesis |
| positive regulation of defense response |
| neuron projection morphogenesis |
| immune response-regulating cell surface receptor signaling pathway |
| plasma membrane bounded cell projection morphogenesis |
| regulation of cell morphogenesis |
| cell projection morphogenesis |
| regulation of neuron projection development |
| positive regulation of cell migration |
| positive regulation of multi-organism process |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of anatomical structure size |
| cell part morphogenesis |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| regulation of response to biotic stimulus |
| positive regulation of cell motility |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| cellular response to organic cyclic compound |
| positive regulation of MAPK cascade |
| positive regulation of locomotion |
| cell morphogenesis involved in differentiation |
| immune response-activating signal transduction |
| positive regulation of kinase activity |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| activation of immune response |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of transferase activity |
| regulation of neuron differentiation |
| neuron projection development |
| regulation of cell adhesion |
| regulation of plasma membrane bounded cell projection organization |
| positive regulation of cell death |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| regulation of MAPK cascade |
| regulation of defense response |
| regulation of multi-organism process |
| regulation of protein kinase activity |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of cell migration |
| positive regulation of immune response |
| regulation of kinase activity |
| regulation of cell motility |
| response to organic cyclic compound |
| regulation of nervous system development |
| regulation of cell development |
| regulation of cellular component biogenesis |
| cell migration |
| positive regulation of cell differentiation |
| protein phosphorylation |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| cell projection organization |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| phosphorylation |
| regulation of organelle organization |
| locomotion |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| ATP binding |
| generation of neurons |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.508 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/694
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/26 |
| bone | 0/26 |
| breast | 0/30 |
| central nervous system | 0/49 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/11 |
| fibroblast | 0/1 |
| gastric | 0/14 |
| kidney | 0/18 |
| liver | 0/19 |
| lung | 0/72 |
| lymphocyte | 0/16 |
| ovary | 0/25 |
| pancreas | 0/22 |
| peripheral nervous system | 0/15 |
| plasma cell | 0/12 |
| prostate | 0/1 |
| skin | 0/20 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/28 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16410
- Expression level (log2 read counts): 2.05
Expression Distribution
PAK3 Expression in NALM6 Cells: 2.05
