PAK7

Entrez Summary: N/A
UniProt Summary: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. {ECO:0000269|PubMed:12897128, ECO:0000269|PubMed:16014608, ECO:0000269|PubMed:16581795, ECO:0000269|PubMed:18465753, ECO:0000269|PubMed:20564219}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Rac GTPase binding
negative regulation of extrinsic apoptotic signaling pathway
memory
stress-activated protein kinase signaling cascade
learning
regulation of extrinsic apoptotic signaling pathway
locomotory behavior
negative regulation of apoptotic signaling pathway
learning or memory
synapse
cognition
activation of protein kinase activity
protein serine/threonine kinase activity
signal transduction by protein phosphorylation
regulation of apoptotic signaling pathway
regulation of cell growth
positive regulation of protein kinase activity
cell population proliferation
behavior
positive regulation of kinase activity
positive regulation of transferase activity
regulation of growth
regulation of MAPK cascade
regulation of protein kinase activity
regulation of kinase activity
negative regulation of apoptotic process
negative regulation of programmed cell death
apoptotic process
cell migration
protein phosphorylation
regulation of transferase activity
negative regulation of cell death
positive regulation of protein phosphorylation
programmed cell death
positive regulation of phosphorylation
localization of cell
cell motility
cell death
cytoskeleton organization
positive regulation of phosphate metabolic process