PARD3
Gene Information
- Official Symbol: PARD3
- Official Name: par-3 family cell polarity regulator
- Aliases and Previous Symbols: N/A
- Entrez ID: 56288
- UniProt: Q8TEW0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and direct polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| DUF3534 |
| PDZ |
GO Terms
| internode region of axon |
| establishment of centrosome localization |
| asymmetric cell division |
| positive regulation of myelination |
| negative regulation of peptidyl-threonine phosphorylation |
| apical junction complex |
| peripheral nervous system axon ensheathment |
| myelination in peripheral nervous system |
| axonal growth cone |
| protein kinase C-activating G protein-coupled receptor signaling pathway |
| Schwann cell development |
| centrosome localization |
| microtubule organizing center localization |
| establishment of epithelial cell polarity |
| Schwann cell differentiation |
| bicellular tight junction assembly |
| tight junction assembly |
| tight junction organization |
| phosphatidylinositol-3,4,5-trisphosphate binding |
| phosphatidylinositol-3-phosphate binding |
| regulation of myelination |
| regulation of peptidyl-threonine phosphorylation |
| apical junction assembly |
| establishment or maintenance of epithelial cell apical/basal polarity |
| establishment or maintenance of apical/basal cell polarity |
| establishment or maintenance of bipolar cell polarity |
| positive regulation of nervous system process |
| adherens junction |
| peripheral nervous system development |
| endomembrane system |
| phosphatidylinositol-4,5-bisphosphate binding |
| protein phosphatase binding |
| phosphatidylinositol binding |
| transforming growth factor beta receptor signaling pathway |
| cell-cell junction assembly |
| cell-cell adherens junction |
| myelination |
| glial cell development |
| ensheathment of neurons |
| axon ensheathment |
| establishment of cell polarity |
| bicellular tight junction |
| cell cortex |
| regulation of nervous system process |
| cell-cell junction organization |
| cellular response to transforming growth factor beta stimulus |
| protein targeting to membrane |
| response to transforming growth factor beta |
| cell junction assembly |
| glial cell differentiation |
| cell-cell junction |
| establishment or maintenance of cell polarity |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| cell junction organization |
| gliogenesis |
| establishment of protein localization to membrane |
| apical plasma membrane |
| protein targeting |
| establishment of organelle localization |
| cytoskeleton |
| axonogenesis |
| neuronal cell body |
| negative regulation of protein phosphorylation |
| axon development |
| cell morphogenesis involved in neuron differentiation |
| negative regulation of phosphorylation |
| microtubule cytoskeleton organization |
| protein localization to membrane |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| cell division |
| cellular response to growth factor stimulus |
| cell part morphogenesis |
| response to growth factor |
| positive regulation of nervous system development |
| cell junction |
| cell morphogenesis involved in differentiation |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| organelle localization |
| regulation of system process |
| negative regulation of protein modification process |
| protein-containing complex |
| neuron projection development |
| microtubule-based process |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| neuron development |
| cellular component morphogenesis |
| regulation of cellular localization |
| regulation of nervous system development |
| cell adhesion |
| biological adhesion |
| intracellular protein transport |
| neuron differentiation |
| negative regulation of cellular protein metabolic process |
| identical protein binding |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| cellular response to endogenous stimulus |
| G protein-coupled receptor signaling pathway |
| cell cycle |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| neurogenesis |
| cell development |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 1/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4055
- Expression level (log2 read counts): 5.48
Expression Distribution
PARD3 Expression in NALM6 Cells: 5.48
