PASK

Gene Information

Official Symbol: PASK
Official Name: PAS domain containing serine/threonine kinase
Aliases and Previous Symbols: N/A
Entrez ID: 23178
UniProt: Q96RG2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
UniProt Summary: Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation. {ECO:0000269|PubMed:16275910, ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:17595531, ECO:0000269|PubMed:20943661, ECO:0000269|PubMed:21181396, ECO:0000269|PubMed:21418524}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16172
Expression level (log2 read counts): 6.26

Expression Distribution

Screen	Score
UM131593 0.2μM R03 exp106	-1.75
Mdivi-1 15μM R05 exp217	-1.71
Taxol 0.002μM R01 exp54	1.79

PAS
Pkinase Tyr
Pkinase

negative regulation of glycogen biosynthetic process
negative regulation of glycogen metabolic process
regulation of glucagon secretion
regulation of respiratory gaseous exchange
regulation of glycogen biosynthetic process
regulation of glucan biosynthetic process
energy homeostasis
regulation of glycogen metabolic process
regulation of polysaccharide biosynthetic process
negative regulation of cellular carbohydrate metabolic process
regulation of polysaccharide metabolic process
negative regulation of carbohydrate metabolic process
phosphatidylinositol binding
regulation of carbohydrate biosynthetic process
regulation of glucose metabolic process
positive regulation of translation
regulation of cellular carbohydrate metabolic process
positive regulation of cellular amide metabolic process
regulation of generation of precursor metabolites and energy
protein autophosphorylation
regulation of carbohydrate metabolic process
regulation of peptide hormone secretion
regulation of hormone secretion
multicellular organismal homeostasis
regulation of translation
protein serine/threonine kinase activity
regulation of cellular amide metabolic process
regulation of small molecule metabolic process
regulation of peptide secretion
posttranscriptional regulation of gene expression
regulation of hormone levels
regulation of peptide transport
regulation of secretion by cell
regulation of secretion
protein phosphorylation
phosphorylation
negative regulation of cellular macromolecule biosynthetic process
negative regulation of macromolecule biosynthetic process
ATP binding
negative regulation of cellular biosynthetic process