PAX1

Entrez Summary: This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. This gene plays a role in pattern formation during embryogenesis and may be essential for development of the vertebral column. This gene is silenced by methylation in ovarian and cervical cancers and may be a tumor suppressor gene. Mutations in this gene are also associated with vertebral malformations. [provided by RefSeq, Mar 2012].
UniProt Summary: This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sclerotome development
parathyroid gland development
CD8-positive, alpha-beta T cell differentiation
CD8-positive, alpha-beta T cell activation
CD4-positive, alpha-beta T cell differentiation
CD4-positive, alpha-beta T cell activation
thymus development
alpha-beta T cell differentiation
alpha-beta T cell activation
somitogenesis
somite development
segmentation
bone morphogenesis
endocrine system development
T cell differentiation
bone development
anterior/posterior pattern specification
mesenchyme development
T cell activation
lymphocyte differentiation
skeletal system morphogenesis
leukocyte differentiation
regionalization
lymphocyte activation
gland development
pattern specification process
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription by RNA polymerase II
skeletal system development
RNA polymerase II proximal promoter sequence-specific DNA binding
cell population proliferation
hemopoiesis
hematopoietic or lymphoid organ development
chordate embryonic development
transcription, DNA-templated
nucleic acid-templated transcription
immune system development
embryo development ending in birth or egg hatching
RNA biosynthetic process
anatomical structure formation involved in morphogenesis