PCOLCE2

Entrez Summary: N/A
UniProt Summary: Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1. {ECO:0000269|PubMed:12393877}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hippuristanol 0.12μM R08 exp488	-2.42
GW501516 25μM R06 exp285	-1.86
UM131593 0.2μM R03 exp106	-1.81
Ammonium tetrathiomolybdate 10μM R08 exp448	2.12

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CUB
NTR

peptidase activator activity
collagen binding
response to leukemia inhibitory factor
cellular response to leukemia inhibitory factor
heparin binding
positive regulation of peptidase activity
positive regulation of proteolysis
regulation of peptidase activity
regulation of proteolysis
positive regulation of hydrolase activity
cellular response to cytokine stimulus
response to cytokine
regulation of hydrolase activity
positive regulation of catalytic activity
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
positive regulation of molecular function
extracellular region