PDGFD

Gene Information

Official Symbol: PDGFD
Official Name: platelet derived growth factor D
Aliases and Previous Symbols: N/A
Entrez ID: 80310
UniProt: Q9GZP0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). {ECO:0000250, ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:15271796}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13252
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
A-395 10μM R05 exp218	-1.88
BN82002 4μM R07 exp340	1.79

positive regulation of monocyte extravasation
positive regulation of smooth muscle cell chemotaxis
regulation of monocyte extravasation
positive regulation of glomerular mesangial cell proliferation
regulation of smooth muscle cell chemotaxis
positive regulation of cell proliferation involved in kidney development
regulation of glomerular mesangial cell proliferation
positive regulation of glomerulus development
regulation of cell proliferation involved in kidney development
regulation of glomerulus development
platelet-derived growth factor receptor binding
positive regulation of cellular extravasation
cellular response to platelet-derived growth factor stimulus
response to platelet-derived growth factor
positive regulation of mononuclear cell migration
positive regulation of protein autophosphorylation
regulation of cellular extravasation
platelet-derived growth factor receptor signaling pathway
positive regulation of smooth muscle cell migration
positive regulation of kidney development
regulation of mononuclear cell migration
regulation of protein autophosphorylation
positive regulation of fibroblast proliferation
regulation of kidney development
regulation of smooth muscle cell migration
cellular response to amino acid stimulus
cellular response to hydrogen peroxide
regulation of fibroblast proliferation
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of smooth muscle cell proliferation
positive regulation of cell division
response to amino acid
cellular response to antibiotic
response to hydrogen peroxide
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of leukocyte migration
cellular response to reactive oxygen species
regulation of smooth muscle cell proliferation
positive regulation of chemotaxis
cellular response to transforming growth factor beta stimulus