PELI3

Entrez Summary: The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011].
UniProt Summary: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. {ECO:0000269|PubMed:12874243, ECO:0000269|PubMed:17675297}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BI-6727 0.001μM R01 exp42	-1.99
MS023 7μM R03 exp135	-1.74

regulation of Toll signaling pathway
Toll signaling pathway
negative regulation of tumor necrosis factor-mediated signaling pathway
protein K63-linked ubiquitination
regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of cytokine-mediated signaling pathway
negative regulation of response to cytokine stimulus
interleukin-1-mediated signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway
regulation of cytokine-mediated signaling pathway
cellular response to interleukin-1
regulation of response to cytokine stimulus
response to interleukin-1
ubiquitin protein ligase activity
negative regulation of apoptotic signaling pathway
protein polyubiquitination
regulation of apoptotic signaling pathway
cytokine-mediated signaling pathway
protein ubiquitination
protein modification by small protein conjugation
negative regulation of apoptotic process
negative regulation of programmed cell death
protein modification by small protein conjugation or removal
negative regulation of cell death
cellular response to cytokine stimulus
response to cytokine
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of apoptotic process
regulation of programmed cell death
negative regulation of response to stimulus
regulation of cell death