PGLYRP4

Gene Information

Official Symbol: PGLYRP4
Official Name: peptidoglycan recognition protein 4
Aliases and Previous Symbols: N/A
Entrez ID: 57115
UniProt: Q96LB8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity. {ECO:0000269|PubMed:16354652}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10163
Expression level (log2 read counts): -7.68

Expression Distribution

positive regulation of cytolysis in other organism
N-acetylmuramoyl-L-alanine amidase activity
negative regulation of natural killer cell differentiation
negative regulation of natural killer cell differentiation involved in immune response
regulation of cytolysis in other organism
regulation of natural killer cell differentiation involved in immune response
peptidoglycan receptor activity
peptidoglycan catabolic process
peptidoglycan metabolic process
negative regulation of natural killer cell activation
positive regulation of cytolysis
detection of bacterium
regulation of natural killer cell differentiation
positive regulation of killing of cells of other organism
detection of other organism
regulation of cytolysis
peptidoglycan binding
regulation of killing of cells of other organism
detection of external biotic stimulus
detection of biotic stimulus
regulation of natural killer cell activation
negative regulation of interferon-gamma production
disruption of cells of other organism
killing of cells of other organism
negative regulation of lymphocyte differentiation
glycosaminoglycan catabolic process
antimicrobial humoral immune response mediated by antimicrobial peptide
aminoglycan catabolic process
positive regulation of cell killing
cell killing
defense response to Gram-positive bacterium
regulation of interferon-gamma production
negative regulation of leukocyte differentiation
regulation of cell killing
antimicrobial humoral response
negative regulation of immune effector process
pattern recognition receptor signaling pathway
negative regulation of hemopoiesis
negative regulation of lymphocyte activation
negative regulation of immune response