PGM2L1

Entrez Summary: N/A
UniProt Summary: Glucose 1,6-bisphosphate synthase using 1,3- bisphosphoglycerate as a phosphate donor and a series of 1- phosphate sugars as acceptors, including glucose 1-phosphate, mannose 1-phosphate, ribose 1-phosphate and deoxyribose 1- phosphate. 5 or 6-phosphosugars are bad substrates, with the exception of glucose 6-phosphate. Also synthesizes ribose 1,5- bisphosphate. Has only low phosphopentomutase and phosphoglucomutase activities. {ECO:0000269|PubMed:17804405, ECO:0000269|PubMed:18927083}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

intramolecular transferase activity, phosphotransferases
glucose-1,6-bisphosphate synthase activity
galactose catabolic process
galactose metabolic process
glycogen catabolic process
glucan catabolic process
glycogen biosynthetic process
glucan biosynthetic process
cellular polysaccharide catabolic process
polysaccharide catabolic process
glucose catabolic process to pyruvate
NADH regeneration
canonical glycolysis
glycolytic process through glucose-6-phosphate
glycolytic process through fructose-6-phosphate
glucose catabolic process
NADH metabolic process
cellular carbohydrate catabolic process
glycolytic process
ATP generation from ADP
cellular polysaccharide biosynthetic process
polysaccharide biosynthetic process
NAD metabolic process
glycogen metabolic process
cellular glucan metabolic process
glucan metabolic process
ADP metabolic process
hexose catabolic process
cellular carbohydrate biosynthetic process
nucleoside diphosphate phosphorylation
nucleotide phosphorylation
purine ribonucleoside diphosphate metabolic process
monosaccharide catabolic process
purine nucleoside diphosphate metabolic process
energy reserve metabolic process
ribonucleoside diphosphate metabolic process
pyruvate metabolic process
cellular polysaccharide metabolic process
polysaccharide metabolic process
nucleoside diphosphate metabolic process