PHF19

Gene Information

Official Symbol: PHF19
Official Name: PHD finger protein 19
Aliases and Previous Symbols: N/A
Entrez ID: 26147
UniProt: Q5T6S3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys- 36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter. {ECO:0000269|PubMed:15563832, ECO:0000269|PubMed:21143197, ECO:0000269|PubMed:23104054, ECO:0000269|PubMed:23160351}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12370
Expression level (log2 read counts): 6.3

Expression Distribution

Screen	Score
DABN racemic mixture R03 exp93	-1.99
CoCl2 18μM R07 exp346	-1.75
Docetaxel 0.002μM R01 exp45	-1.7
3-Bromopyruvate 7μM R04 exp175	1.72

positive regulation of histone H3-K27 methylation
regulation of histone H3-K27 methylation
ESC/E(Z) complex
nucleosome binding
positive regulation of histone methylation
methylated histone binding
regulation of histone methylation
negative regulation of gene expression, epigenetic
positive regulation of histone modification
positive regulation of chromatin organization
regulation of histone modification
positive regulation of chromosome organization
regulation of chromatin organization
regulation of gene expression, epigenetic
regulation of chromosome organization
sequence-specific DNA binding
positive regulation of organelle organization
DNA-binding transcription factor activity
chromatin organization
chromosome organization
positive regulation of cellular component organization
positive regulation of protein modification process
regulation of organelle organization
positive regulation of transcription, DNA-templated
positive regulation of cellular protein metabolic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of protein metabolic process
negative regulation of gene expression
positive regulation of RNA metabolic process
regulation of protein modification process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process