PHLDA3

Entrez Summary: N/A
UniProt Summary: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor. {ECO:0000269|PubMed:19203586}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphatidylinositol-5-phosphate binding
phosphatidylinositol-3,5-bisphosphate binding
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
phosphatidylinositol-3,4-bisphosphate binding
phosphatidylinositol-3,4,5-trisphosphate binding
phosphatidylinositol-3-phosphate binding
negative regulation of protein kinase B signaling
intrinsic apoptotic signaling pathway by p53 class mediator
intrinsic apoptotic signaling pathway in response to DNA damage
phosphatidylinositol-4,5-bisphosphate binding
signal transduction by p53 class mediator
intrinsic apoptotic signaling pathway
regulation of protein kinase B signaling
apoptotic signaling pathway
negative regulation of intracellular signal transduction
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
cellular response to DNA damage stimulus
apoptotic process
programmed cell death
cell death
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of apoptotic process
regulation of programmed cell death
negative regulation of response to stimulus
regulation of cell death
intracellular signal transduction
cellular response to stress
regulation of intracellular signal transduction