PI4K2B
Gene Information
- Official Symbol: PI4K2B
- Official Name: phosphatidylinositol 4-kinase type 2 beta
- Aliases and Previous Symbols: N/A
- Entrez ID: 55300
- UniProt: Q8TCG2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with other protein family members. This protein is involved in early T cell activation. [provided by RefSeq, Dec 2016].
- UniProt Summary: Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. {ECO:0000269|PubMed:11923287}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 18560
- Expression level (log2 read counts): 5.37
PI4K2B Expression in NALM6 Cells: 5.37
