PIFO

Entrez Summary: N/A
UniProt Summary: During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle-dependent manner. {ECO:0000269|PubMed:20643351}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Ibrutinib 1μM R07 exp372	-2.09
5-Azacytidine 2μM R07 exp330	-1.73
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.89

gamma-tubulin binding
beta-tubulin binding
kinesin binding
ciliary basal body
Rab GTPase binding
trans-Golgi network
cytoplasmic vesicle
protein kinase binding
positive regulation of kinase activity
positive regulation of transferase activity
regulation of cell projection organization
regulation of kinase activity
regulation of transferase activity
positive regulation of phosphorylation
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
cell projection organization
positive regulation of catalytic activity
regulation of phosphorylation
positive regulation of molecular function
regulation of phosphate metabolic process
regulation of phosphorus metabolic process