PINX1
Gene Information
- Official Symbol: PINX1
- Official Name: PIN2 (TERF1) interacting telomerase inhibitor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 54984
- UniProt: Q96BK5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. {ECO:0000269|PubMed:15381700, ECO:0000269|PubMed:17198684, ECO:0000269|PubMed:19117989, ECO:0000269|PubMed:19265708, ECO:0000269|PubMed:19393617, ECO:0000269|PubMed:19553660}.
Pfam Domains GO Terms
Pfam Domains
| G-patch |
| G-patch 2 |
GO Terms
| positive regulation of telomeric DNA binding |
| positive regulation of protein localization to nucleolus |
| regulation of telomeric DNA binding |
| telomerase inhibitor activity |
| protein localization to nucleolus |
| regulation of protein localization to nucleolus |
| negative regulation of telomerase activity |
| protein localization to chromosome, telomeric region |
| negative regulation of telomere maintenance via telomerase |
| telomere maintenance via telomerase |
| telomerase RNA binding |
| negative regulation of telomere maintenance via telomere lengthening |
| nuclear chromosome |
| telomere maintenance via telomere lengthening |
| RNA-dependent DNA biosynthetic process |
| negative regulation of telomere maintenance |
| negative regulation of DNA biosynthetic process |
| mitotic metaphase plate congression |
| chromosome, telomeric region |
| regulation of telomerase activity |
| regulation of telomere maintenance via telomerase |
| metaphase plate congression |
| positive regulation of DNA binding |
| regulation of telomere maintenance via telomere lengthening |
| protein localization to chromosome |
| establishment of chromosome localization |
| negative regulation of protein ubiquitination |
| chromosome localization |
| positive regulation of protein localization to nucleus |
| regulation of telomere maintenance |
| negative regulation of protein modification by small protein conjugation or removal |
| kinetochore |
| negative regulation of G2/M transition of mitotic cell cycle |
| condensed chromosome kinetochore |
| telomere maintenance |
| negative regulation of cell cycle G2/M phase transition |
| telomere organization |
| mitotic sister chromatid segregation |
| nuclear chromosome, telomeric region |
| DNA biosynthetic process |
| regulation of DNA biosynthetic process |
| regulation of protein localization to nucleus |
| spindle |
| negative regulation of DNA metabolic process |
| regulation of DNA binding |
| negative regulation of chromosome organization |
| sister chromatid segregation |
| mitotic nuclear division |
| protein localization to nucleus |
| positive regulation of binding |
| regulation of G2/M transition of mitotic cell cycle |
| regulation of protein ubiquitination |
| regulation of cell cycle G2/M phase transition |
| negative regulation of mitotic cell cycle phase transition |
| nuclear chromosome segregation |
| regulation of protein modification by small protein conjugation or removal |
| negative regulation of cell cycle phase transition |
| protein-containing complex binding |
| chromosome segregation |
| negative regulation of transferase activity |
| nuclear division |
| regulation of protein stability |
| negative regulation of mitotic cell cycle |
| organelle fission |
| positive regulation of cellular protein localization |
| negative regulation of cell cycle process |
| anatomical structure homeostasis |
| regulation of chromosome organization |
| regulation of DNA metabolic process |
| establishment of organelle localization |
| negative regulation of organelle organization |
| regulation of binding |
| regulation of mitotic cell cycle phase transition |
| regulation of cell cycle phase transition |
| regulation of cellular protein localization |
| negative regulation of cell cycle |
| organelle localization |
| negative regulation of protein modification process |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| negative regulation of cell population proliferation |
| mitotic cell cycle |
| negative regulation of cellular component organization |
| protein localization to organelle |
| DNA metabolic process |
| regulation of cell cycle process |
| negative regulation of catalytic activity |
| nucleolus |
| regulation of cellular localization |
| regulation of transferase activity |
| cell cycle process |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| chromosome organization |
| nucleobase-containing compound biosynthetic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| cell cycle |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| cellular protein localization |
| cellular macromolecule localization |
| regulation of cell population proliferation |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| establishment of localization in cell |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| CR131-b 0.005μM R08 exp474 | 1.78 |
| Monensin 0.3μM R08 exp507 | 1.78 |
| ML-792 0.2μM R08 exp505 | 2.25 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10146
- Expression level (log2 read counts): 4.95
Expression Distribution
PINX1 Expression in NALM6 Cells: 4.95
