PITX1

Entrez Summary: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008].
UniProt Summary: Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. {ECO:0000250|UniProtKB:P56673}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
RRM1	0.469
HGC6.3	0.444

Homeobox
OAR

branchiomeric skeletal muscle development
myoblast fate commitment
embryonic hindlimb morphogenesis
myoblast differentiation
hindlimb morphogenesis
pituitary gland development
RNA polymerase II transcription factor binding
diencephalon development
endocrine system development
skeletal muscle tissue development
embryonic limb morphogenesis
embryonic appendage morphogenesis
skeletal muscle organ development
limb morphogenesis
appendage morphogenesis
cartilage development
appendage development
limb development
transcription factor complex
connective tissue development
cell fate commitment
striated muscle tissue development
muscle organ development
muscle tissue development
forebrain development
gland development
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
muscle structure development
skeletal system development
RNA polymerase II proximal promoter sequence-specific DNA binding
embryonic morphogenesis
DNA-binding transcription factor activity
brain development
head development
nucleolus
embryo development
central nervous system development
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II