PKIG

Gene Information

Official Symbol: PKIG
Official Name: cAMP-dependent protein kinase inhibitor gamma
Aliases and Previous Symbols: N/A
Entrez ID: 11142
UniProt: Q9Y2B9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10265
Expression level (log2 read counts): 3.9

Expression Distribution

Screen	Score
Cycloheximide 0.02μM R00 exp14	-1.72
Epigallocatechin gallate 20μM R05 exp230	-1.71

negative regulation of cAMP-dependent protein kinase activity
cAMP-dependent protein kinase inhibitor activity
negative regulation of protein import
negative regulation of protein import into nucleus
regulation of cAMP-dependent protein kinase activity
negative regulation of nucleocytoplasmic transport
negative regulation of protein localization to nucleus
negative regulation of intracellular protein transport
regulation of protein import into nucleus
regulation of protein import
negative regulation of intracellular transport
regulation of nucleocytoplasmic transport
negative regulation of cellular protein localization
regulation of protein localization to nucleus
negative regulation of protein serine/threonine kinase activity
negative regulation of protein transport
negative regulation of establishment of protein localization
negative regulation of protein kinase activity
regulation of intracellular protein transport
negative regulation of kinase activity
negative regulation of transferase activity
regulation of intracellular transport
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of transport
regulation of protein serine/threonine kinase activity
regulation of cellular protein localization
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
negative regulation of catalytic activity
regulation of protein kinase activity
negative regulation of transcription by RNA polymerase II
regulation of kinase activity
regulation of cellular localization
regulation of transferase activity
regulation of protein localization