PLEKHA7

Entrez Summary: N/A
UniProt Summary: Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site. {ECO:0000269|PubMed:19041755}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

zonula adherens maintenance
adherens junction maintenance
delta-catenin binding
zonula adherens
cell-cell junction maintenance
pore complex
cell junction maintenance
epithelial cell-cell adhesion
pore complex assembly
cell-cell adhesion mediated by cadherin
cellular component maintenance
adherens junction organization
cell-cell junction organization
cell junction organization
centrosome
cell-cell adhesion
cell junction
cell adhesion
biological adhesion
protein-containing complex assembly
protein-containing complex subunit organization