PLEKHF1

Entrez Summary: N/A
UniProt Summary: May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase- independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8. {ECO:0000269|PubMed:16188880}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

FYVE
PH

phosphatidylinositol-5-phosphate binding
phosphatidylinositol-4-phosphate binding
phosphatidylinositol-3-phosphate binding
positive regulation of intrinsic apoptotic signaling pathway
endosome organization
phosphatidylinositol binding
positive regulation of autophagy
regulation of intrinsic apoptotic signaling pathway
positive regulation of apoptotic signaling pathway
protein localization to plasma membrane
endosome membrane
protein localization to cell periphery
lysosome
endosome
lysosomal membrane
vesicle organization
regulation of autophagy
positive regulation of cellular catabolic process
regulation of apoptotic signaling pathway
endomembrane system organization
positive regulation of catabolic process
protein localization to membrane
positive regulation of apoptotic process
positive regulation of programmed cell death
perinuclear region of cytoplasm
positive regulation of cell death
regulation of cellular catabolic process
apoptotic process
regulation of catabolic process
positive regulation of intracellular signal transduction
programmed cell death
cell death
regulation of apoptotic process
regulation of programmed cell death
cellular protein localization
cellular macromolecule localization
positive regulation of signal transduction
regulation of cell death
positive regulation of cell communication
positive regulation of signaling