PLEKHH2

Entrez Summary: N/A
UniProt Summary: In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of actin filament depolymerization
regulation of actin filament depolymerization
cortical actin cytoskeleton
negative regulation of protein depolymerization
negative regulation of protein complex disassembly
regulation of protein depolymerization
regulation of protein complex disassembly
negative regulation of supramolecular fiber organization
negative regulation of cytoskeleton organization
lamellipodium
regulation of actin polymerization or depolymerization
regulation of actin filament length
regulation of actin filament organization
actin binding
nuclear body
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
negative regulation of organelle organization
regulation of cellular component size
regulation of actin filament-based process
regulation of anatomical structure size
regulation of cytoskeleton organization
negative regulation of cellular component organization
identical protein binding
regulation of organelle organization