PLG

Entrez Summary: The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009].
UniProt Summary: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. {ECO:0000269|PubMed:14699093}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
IU1-C 25μM R04 exp183	-1.77
CCCP 0.1μM R00 exp10	2.28

interaction with symbiont via secreted substance
proteasome core complex binding
symbiotic process mediated by secreted substance
other organism cell membrane
positive regulation of fibrinolysis
extrinsic component of external side of plasma membrane
protein antigen binding
negative regulation of cell-cell adhesion mediated by cadherin
negative regulation of fibrinolysis
regulation of fibrinolysis
apolipoprotein binding
regulation of cell-cell adhesion mediated by cadherin
fibrinolysis
positive regulation of blood coagulation
positive regulation of hemostasis
positive regulation of coagulation
negative regulation of blood coagulation
negative regulation of hemostasis
negative regulation of coagulation
positive regulation of wound healing
serine-type peptidase activity
negative regulation of cell-substrate adhesion
positive regulation of response to wounding
extracellular matrix disassembly
platelet alpha granule lumen
negative regulation of wound healing
endopeptidase activity
interaction with symbiont
regulation of blood coagulation
regulation of hemostasis
regulation of coagulation
negative regulation of response to wounding
kinase binding
tissue remodeling
chaperone binding
platelet degranulation
regulation of wound healing
blood microparticle
serine-type endopeptidase activity
regulation of response to wounding