PLVAP

Entrez Summary: N/A
UniProt Summary: Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability. {ECO:0000269|PubMed:15155804}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Brefeldin A 0.02μM R00 exp8	-2.75
Atovaquone 15μM R08 exp451	-1.84
Rifampicin 10μM R00 exp32	-1.82
Dihydrosphingosine 8μM R08 exp476	-1.72
Epigallocatechin gallate 20μM R05 exp230	2.6

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein kinase C signaling
positive regulation of cellular extravasation
regulation of cellular extravasation
caveola
tumor necrosis factor-mediated signaling pathway
positive regulation of leukocyte migration
regulation of leukocyte migration
cellular response to tumor necrosis factor
response to tumor necrosis factor
MAPK cascade
signal transduction by protein phosphorylation
positive regulation of cell migration
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of locomotion
cell surface
cytokine-mediated signaling pathway
perinuclear region of cytoplasm
regulation of cell migration
protein homodimerization activity
regulation of cell motility
protein phosphorylation
regulation of locomotion
regulation of cellular component movement
cellular response to cytokine stimulus
response to cytokine
positive regulation of immune system process
phosphorylation
regulation of immune system process
intracellular signal transduction