PLXNA3

Entrez Summary: This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013].
UniProt Summary: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
Staurosporine 0.02μM R08 exp524	-1.77
Menadione 5μM R06 exp292	1.72

trigeminal nerve structural organization
trigeminal nerve morphogenesis
branchiomotor neuron axon guidance
pyramidal neuron development
pyramidal neuron differentiation
facial nerve structural organization
cranial nerve structural organization
semaphorin receptor complex
facial nerve morphogenesis
facial nerve development
semaphorin-plexin signaling pathway involved in axon guidance
trigeminal nerve development
semaphorin receptor activity
semaphorin-plexin signaling pathway involved in neuron projection guidance
anatomical structure arrangement
preganglionic parasympathetic fiber development
parasympathetic nervous system development
negative regulation of axon extension involved in axon guidance
negative regulation of axon guidance
motor neuron axon guidance
cranial nerve morphogenesis
forebrain neuron development
regulation of axon extension involved in axon guidance
semaphorin-plexin signaling pathway
negative regulation of axon extension
regulation of axon guidance
negative chemotaxis
autonomic nervous system development
forebrain neuron differentiation
cranial nerve development
negative regulation of chemotaxis
neuron projection extension
forebrain generation of neurons
negative regulation of axonogenesis
nerve development
central nervous system neuron development
hippocampus development
positive regulation of axonogenesis
developmental cell growth
cell growth