PLXND1

Entrez Summary: N/A
UniProt Summary: Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E. {ECO:0000250, ECO:0000269|PubMed:20385769}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dichotomous subdivision of terminal units involved in salivary gland branching
dichotomous subdivision of an epithelial terminal unit
semaphorin receptor complex
semaphorin-plexin signaling pathway involved in axon guidance
semaphorin receptor activity
semaphorin-plexin signaling pathway involved in neuron projection guidance
branching involved in salivary gland morphogenesis
positive regulation of transcription of Notch receptor target
lamellipodium membrane
branching involved in blood vessel morphogenesis
salivary gland morphogenesis
salivary gland development
semaphorin-plexin signaling pathway
exocrine system development
coronary vasculature development
aorta development
endothelial cell migration
outflow tract morphogenesis
epithelial cell migration
artery development
positive regulation of axonogenesis
epithelium migration
synapse assembly
positive regulation of protein binding
tissue migration
gland morphogenesis
cardiac septum development
Notch signaling pathway
branching morphogenesis of an epithelial tube
regulation of cell shape
positive regulation of cell morphogenesis involved in differentiation
morphogenesis of a branching epithelium
morphogenesis of a branching structure
cardiac chamber development
ameboidal-type cell migration
positive regulation of binding
lamellipodium
regulation of axonogenesis
regulation of protein binding
protein domain specific binding