PMS1

• Official Symbol: PMS1
• Official Name: PMS1 homolog 1, mismatch repair system component
• Aliases and Previous Symbols: N/A
• Entrez ID: 5378
• UniProt: P54277
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. [provided by RefSeq, Jul 2008].
• UniProt Summary: Probably involved in the repair of mismatches in DNA. {ECO:0000269|PubMed:10748105}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 18967
• Expression level (log2 read counts): 6.02

Expression Distribution

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PMS1 Expression in NALM6 Cells: 6.02