PNMT

Entrez Summary: The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012].
UniProt Summary: Converts noradrenaline to adrenaline.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phenylethanolamine N-methyltransferase activity
epinephrine biosynthetic process
epinephrine metabolic process
catecholamine biosynthetic process
catechol-containing compound biosynthetic process
phenol-containing compound biosynthetic process
catechol-containing compound metabolic process
catecholamine metabolic process
phenol-containing compound metabolic process
organic hydroxy compound biosynthetic process
methylation
organic hydroxy compound metabolic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process