PNOC

Entrez Summary: N/A
UniProt Summary: Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. {ECO:0000250|UniProtKB:P55791}. Orphanin FQ2: Has potent analgesic activity. {ECO:0000250|UniProtKB:Q64387}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CoCl2 18μM R07 exp346	1.75
CHIR-124 0.04μM R06 exp272	1.78

opioid receptor binding
opioid peptide activity
neuropeptide hormone activity
axon terminus
neuropeptide signaling pathway
female pregnancy
multi-multicellular organism process
neuronal cell body
chemical synaptic transmission
dendrite
anterograde trans-synaptic signaling
trans-synaptic signaling
synaptic signaling
sensory perception
multi-organism reproductive process
cell-cell signaling
G protein-coupled receptor signaling pathway
nervous system process
reproductive process
reproduction
extracellular region
system process