PODXL2

Entrez Summary: N/A
UniProt Summary: Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L- selectins. {ECO:0000269|PubMed:18606703}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
THZ1 0.06μM R08 exp531	-1.72
Fas-L 44ng/ml R08 exp482	1.75

leukocyte tethering or rolling
leukocyte adhesion to vascular endothelial cell
glycosaminoglycan binding
cellular extravasation
leukocyte cell-cell adhesion
Golgi lumen
leukocyte migration
cell-cell adhesion
cell adhesion
biological adhesion
cell migration
localization of cell
cell motility
locomotion
integral component of plasma membrane
movement of cell or subcellular component