POLM

Entrez Summary: N/A
UniProt Summary: Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. {ECO:0000269|PubMed:12640116, ECO:0000269|PubMed:12888504, ECO:0000269|PubMed:17483519, ECO:0000269|PubMed:17915942}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

somatic hypermutation of immunoglobulin genes
somatic diversification of immune receptors via somatic mutation
DNA-directed DNA polymerase activity
somatic diversification of immunoglobulins
somatic diversification of immune receptors
double-strand break repair via nonhomologous end joining
non-recombinational repair
B cell differentiation
DNA biosynthetic process
B cell activation
immunoglobulin production
production of molecular mediator of immune response
double-strand break repair
DNA recombination
lymphocyte differentiation
leukocyte differentiation
lymphocyte activation
DNA repair
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
DNA metabolic process
cellular response to DNA damage stimulus
leukocyte activation
cell activation
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
DNA binding
cellular nitrogen compound biosynthetic process
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process