PON3

Entrez Summary: This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008].
UniProt Summary: Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. {ECO:0000269|PubMed:15772423}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Arylesterase
SGL

3,4-dihydrocoumarin hydrolase activity
coumarin catabolic process
auxin catabolic process
phenylpropanoid catabolic process
phenylacetate catabolic process
aryldialkylphosphatase activity
auxin metabolic process
acyl-L-homoserine-lactone lactonohydrolase activity
negative regulation of superoxide anion generation
toxin catabolic process
arylesterase activity
phenylpropanoid metabolic process
coumarin metabolic process
xenobiotic catabolic process
lipoxygenase pathway
hormone catabolic process
regulation of superoxide anion generation
toxin metabolic process
benzene-containing compound metabolic process
regulation of superoxide metabolic process
negative regulation of reactive oxygen species metabolic process
secondary metabolic process
icosanoid metabolic process
monocarboxylic acid catabolic process
detoxification
xenobiotic metabolic process
fatty acid derivative metabolic process
regulation of reactive oxygen species metabolic process
cellular response to xenobiotic stimulus
hormone metabolic process
carboxylic acid catabolic process
organic acid catabolic process
response to xenobiotic stimulus
dephosphorylation
fatty acid metabolic process
heterocycle catabolic process
small molecule catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
response to toxic substance