PPAPDC1A

Entrez Summary: N/A
UniProt Summary: Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. {ECO:0000269|PubMed:17590538}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Oligomycin-A 2μM R00 exp25	-1.79
GSK626616 14μM R08 exp485	-1.7

phosphatidate phosphatase activity
blastocyst hatching
hatching
organism emergence from protective structure
phospholipid dephosphorylation
phosphatase activity
blastocyst development
Fc-gamma receptor signaling pathway involved in phagocytosis
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
Fc receptor mediated stimulatory signaling pathway
Fc-gamma receptor signaling pathway
lipid modification
Fc receptor signaling pathway
dephosphorylation
phagocytosis
phospholipid metabolic process
in utero embryonic development
immune response-activating cell surface receptor signaling pathway
immune response-regulating cell surface receptor signaling pathway
immune response-activating signal transduction
immune response-regulating signaling pathway
activation of immune response
chordate embryonic development
embryo development ending in birth or egg hatching
positive regulation of immune response
organophosphate metabolic process
cellular lipid metabolic process
embryo development
identical protein binding
immune effector process
regulation of immune response
positive regulation of immune system process
lipid metabolic process
integral component of plasma membrane
regulation of immune system process
vesicle-mediated transport