PPFIA1

Entrez Summary: N/A
UniProt Summary: May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Cytochalasin-B 5μM R07 exp349	-1.85
Epothilone-B 0.0015μM R05 exp231	2.03

SAM 1
SAM 2

negative regulation of stress fiber assembly
negative regulation of protein localization to plasma membrane
negative regulation of actin filament bundle assembly
negative regulation of protein localization to cell periphery
glutamate secretion
negative regulation of protein localization to membrane
presynaptic active zone
acidic amino acid transport
dicarboxylic acid transport
regulation of stress fiber assembly
acid secretion
regulation of actomyosin structure organization
regulation of actin filament bundle assembly
regulation of protein localization to plasma membrane
neurotransmitter secretion
signal release from synapse
negative regulation of cellular protein localization
regulation of protein localization to cell periphery
amino acid transport
cell-matrix adhesion
negative regulation of supramolecular fiber organization
negative regulation of cytoskeleton organization
signal release
neurotransmitter transport
cell-substrate adhesion
regulation of protein localization to membrane
regulation of actin filament organization
organic acid transport
carboxylic acid transport
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
regulation of neurotransmitter levels
negative regulation of organelle organization
regulation of actin filament-based process
focal adhesion
chemical synaptic transmission
anterograde trans-synaptic signaling
trans-synaptic signaling
organic anion transport
synaptic signaling