PPIA

Entrez Summary: This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 24/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	2/28
bone	2/26
breast	2/33
central nervous system	3/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	1/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Expression Distribution

Screen	Score
Bortezomib 0.005μM R00 exp6	-3.03
Nicotinamide 1000μM R03 exp101	1.91

uncoating of virus
exit from host cell
movement in host environment
movement in environment of other organism involved in symbiotic interaction
exit from host
viral release from host cell
membrane fusion involved in viral entry into host cell
fusion of virus membrane with host plasma membrane
multi-organism membrane fusion
establishment of integrated proviral latency
establishment of viral latency
multi-organism membrane organization
virion binding
viral latency
lipid droplet organization
multi-organism cellular process
cyclosporin A binding
positive regulation of viral genome replication
RNA-dependent DNA biosynthetic process
protein refolding
virion assembly
protein peptidyl-prolyl isomerization
interleukin-12-mediated signaling pathway
peptidyl-prolyl cis-trans isomerase activity
cellular response to interleukin-12
response to interleukin-12
peptidyl-proline modification
positive regulation of viral life cycle
regulation of viral genome replication
viral entry into host cell
entry into host cell
entry into host
positive regulation of viral process
DNA biosynthetic process
secretory granule lumen
ficolin-1-rich granule lumen
membrane fusion
unfolded protein binding
vesicle
regulation of viral life cycle