PPP1R14A

Entrez Summary: N/A
UniProt Summary: Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein serine/threonine phosphatase inhibitor activity
negative regulation of phosphoprotein phosphatase activity
negative regulation of protein dephosphorylation
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphoprotein phosphatase activity
regulation of protein dephosphorylation
regulation of phosphatase activity
regulation of dephosphorylation
cellular response to drug
negative regulation of hydrolase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
negative regulation of catalytic activity
response to drug
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of hydrolase activity
regulation of phosphorylation
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process