PPT2

Entrez Summary: This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene. [provided by RefSeq, Feb 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Palm thioest
Abhydrolase 6

palmitoyl hydrolase activity
thiolester hydrolase activity
palmitoyl-(protein) hydrolase activity
macromolecule depalmitoylation
fatty-acyl-CoA biosynthetic process
fatty-acyl-CoA metabolic process
acyl-CoA biosynthetic process
thioester biosynthetic process
purine nucleoside bisphosphate biosynthetic process
nucleoside bisphosphate biosynthetic process
ribonucleoside bisphosphate biosynthetic process
macromolecule deacylation
fatty acid derivative biosynthetic process
lysosomal lumen
thioester metabolic process
acyl-CoA metabolic process
ribonucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
coenzyme biosynthetic process
purine ribonucleotide biosynthetic process
purine nucleotide biosynthetic process
ribonucleotide biosynthetic process
fatty acid derivative metabolic process
ribose phosphate biosynthetic process
purine-containing compound biosynthetic process
sulfur compound biosynthetic process
cofactor biosynthetic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
coenzyme metabolic process
lysosome
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
sulfur compound metabolic process
purine-containing compound metabolic process
cofactor metabolic process
nucleotide metabolic process