PRDM11

Gene Information

Official Symbol: PRDM11
Official Name: PR/SET domain 11
Aliases and Previous Symbols: N/A
Entrez ID: 56981
UniProt: Q9NQV5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May be involved in transcription regulation. {ECO:0000269|PubMed:25499759}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10204
Expression level (log2 read counts): 2.86

Expression Distribution

Screen	Score
TIC10 10μM R08 exp532	-1.88
Nicotinamide 1000μM R03 exp101	-1.73
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	1.81

positive regulation of fibroblast apoptotic process
core promoter binding
regulation of fibroblast apoptotic process
methyltransferase activity
chromatin DNA binding
negative regulation of cell growth
negative regulation of growth
methylation
RNA polymerase II regulatory region sequence-specific DNA binding
chromatin binding
regulation of cell growth
sequence-specific DNA binding
positive regulation of apoptotic process
positive regulation of programmed cell death
regulation of growth
DNA-binding transcription factor activity
positive regulation of cell death
regulation of MAPK cascade
regulation of cell cycle
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
regulation of protein phosphorylation
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
regulation of apoptotic process
negative regulation of biosynthetic process
regulation of programmed cell death
regulation of phosphorylation
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
regulation of cell death
negative regulation of gene expression
positive regulation of RNA metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process