PRDM12

Gene Information

Official Symbol: PRDM12
Official Name: PR/SET domain 12
Aliases and Previous Symbols: N/A
Entrez ID: 59335
UniProt: Q9H4Q4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a transcriptional regulator of sensory neuronal specification that plays a critical role in pain perception. The encoded protein contains an N-terminal PRDI-BF1 and RIZ homology (PR) domain, a SET domain, and three C-terminal C2H2 zinc finger DNA-binding domains. Naturally occurring mutations in this gene are associated with congenital insensitivity to pain (CIP), and hereditary sensory and autonomic neuropathies (HSAN's) affecting peripheral sensory and autonomic neurons. Deregulation of this gene is associated with solid cancers and hematological malignancies including chronic myeloid leukaemia. [provided by RefSeq, Mar 2017].
UniProt Summary: Involved in the positive regulation of histone H3-K9 dimethylation. {ECO:0000269|PubMed:26005867}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15247
Expression level (log2 read counts): -0.78

Expression Distribution

Screen	Score
MS094 2μM R03 exp136	-1.95
BS-181 20μM R08 exp461	1.83

positive regulation of histone H3-K9 dimethylation
regulation of histone H3-K9 dimethylation
histone methyltransferase binding
positive regulation of histone H3-K9 methylation
detection of temperature stimulus involved in sensory perception of pain
detection of temperature stimulus involved in sensory perception
detection of temperature stimulus
sensory perception of temperature stimulus
regulation of histone H3-K9 methylation
positive regulation of histone methylation
methyltransferase activity
regulation of histone methylation
chromatin DNA binding
sensory perception of pain
positive regulation of histone modification
positive regulation of chromatin organization
detection of external stimulus
detection of abiotic stimulus
regulation of histone modification
positive regulation of chromosome organization
response to temperature stimulus
regulation of chromatin organization
methylation
RNA polymerase II regulatory region sequence-specific DNA binding
regulation of chromosome organization
sequence-specific DNA binding
detection of stimulus involved in sensory perception
positive regulation of organelle organization
neuron projection development
DNA-binding transcription factor activity
detection of stimulus
neuron development
sensory perception
neuron differentiation
plasma membrane bounded cell projection organization
cell projection organization
response to abiotic stimulus
positive regulation of cellular component organization
positive regulation of protein modification process
regulation of organelle organization