PRDM9

Entrez Summary: N/A
UniProt Summary: Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
GW501516 25μM R06 exp285	-1.82
FK-506 5μM R07 exp358	1.78

recombination hotspot binding
meiotic gene conversion
regulation of reciprocal meiotic recombination
positive regulation of reciprocal meiotic recombination
gene conversion
positive regulation of meiosis I
regulation of meiosis I
positive regulation of meiotic nuclear division
histone methyltransferase activity (H3-K4 specific)
nucleosome positioning
histone-lysine N-methyltransferase activity
positive regulation of meiotic cell cycle
regulation of meiotic nuclear division
histone H3-K4 methylation
positive regulation of DNA recombination
regulation of meiotic cell cycle
positive regulation of nuclear division
chromatin DNA binding
histone lysine methylation
positive regulation of reproductive process
peptidyl-lysine methylation
histone methylation
regulation of DNA recombination
meiosis I cell cycle process
chromosome
chromatin assembly
protein methylation
protein alkylation
chromatin assembly or disassembly
nucleosome organization
regulation of reproductive process
meiotic cell cycle process
DNA packaging
regulation of nuclear division
positive regulation of DNA metabolic process
transcription regulatory region DNA binding
DNA recombination
meiotic cell cycle
protein-DNA complex subunit organization
macromolecule methylation