PRDX6

Entrez Summary: N/A
UniProt Summary: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. {ECO:0000269|PubMed:10893423, ECO:0000269|PubMed:9497358}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Epigallocatechin gallate 20μM R05 exp230	-3.18
Demecolcine 0.03μM R05 exp228	-1.85
THZ531 0.225μM R08 exp444	-1.71
All-trans-Retinoic-Acid 40μM R07 exp334	1.79

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

peroxiredoxin activity
calcium-independent phospholipase A2 activity
positive regulation of mRNA splicing, via spliceosome
glutathione peroxidase activity
glycerophospholipid catabolic process
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
hydrogen peroxide catabolic process
positive regulation of mRNA processing
peroxidase activity
positive regulation of RNA splicing
phospholipid catabolic process
hydrogen peroxide metabolic process
antibiotic catabolic process
glycerolipid catabolic process
cofactor catabolic process
cell redox homeostasis
positive regulation of mRNA metabolic process
azurophil granule lumen
cellular oxidant detoxification
regulation of mRNA splicing, via spliceosome
cellular detoxification
antibiotic metabolic process
reactive oxygen species metabolic process
detoxification
organophosphate catabolic process
regulation of RNA splicing
regulation of mRNA processing
drug catabolic process
cellular lipid catabolic process
cellular response to toxic substance
cellular response to oxidative stress
ubiquitin protein ligase binding
lipid catabolic process
glycerophospholipid metabolic process
cadherin binding
regulation of mRNA metabolic process
phospholipid metabolic process
glycerolipid metabolic process
response to oxidative stress