PRIM2

Entrez Summary: This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014].
UniProt Summary: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MK-1775 0.32μM R02 exp75	-1.87
Amiloride 100μM R08 exp447	-1.86
UMK57 1μM R01 exp59	-1.84
Dimethyloxaloylglycine 11μM R07 exp314	1.71
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.14

Expression Distribution

DNA primase activity
alpha DNA polymerase:primase complex
DNA replication, synthesis of RNA primer
telomere maintenance via semi-conservative replication
DNA replication initiation
4 iron, 4 sulfur cluster binding
nuclear DNA replication
cell cycle DNA replication
telomere maintenance
telomere organization
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
DNA-dependent DNA replication
DNA replication
mitotic cell cycle phase transition
cell cycle phase transition
anatomical structure homeostasis
mitotic cell cycle process
RNA biosynthetic process
mitotic cell cycle
DNA metabolic process
cellular homeostasis
cell cycle process
chromosome organization
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cell cycle
cellular nitrogen compound biosynthetic process
homeostatic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process