PRKACG

Entrez Summary: Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008].
UniProt Summary: Phosphorylates a large number of substrates in the cytoplasm and the nucleus.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase Tyr
Pkinase

cAMP-dependent protein kinase activity
high-density lipoprotein particle assembly
protein kinase A signaling
cAMP-dependent protein kinase complex
activation of protein kinase A activity
protein kinase A regulatory subunit binding
cellular response to glucagon stimulus
plasma lipoprotein particle assembly
protein-lipid complex assembly
ciliary base
renal water homeostasis
response to glucagon
plasma lipoprotein particle organization
protein-lipid complex subunit organization
intercellular bridge
multicellular organismal water homeostasis
regulation of plasma lipoprotein particle levels
water homeostasis
renal system process
stimulatory C-type lectin receptor signaling pathway
innate immune response activating cell surface receptor signaling pathway
male gonad development
development of primary male sexual characteristics
male sex differentiation
peptidyl-serine phosphorylation
peptidyl-serine modification
gonad development
development of primary sexual characteristics
innate immune response-activating signal transduction
activation of innate immune response
sex differentiation
cellular response to peptide hormone stimulus
blood coagulation
coagulation
hemostasis
multicellular organismal homeostasis
cellular response to peptide
activation of protein kinase activity
positive regulation of innate immune response
positive regulation of response to biotic stimulus